The possibility of directing the patient to the clinical research center increases the therapeutic possibilities. Patients have access to modern therapy and more frequent specialist monitoring in this way. The possibility of establishing cooperation with a clinical trial center extends the range of available methods of diagnosis and treatment. The cooperation between the attending physician and the clinical trial center must be bilateral. Conducted activities at the clinical trial center must be clear and transparent to the physician conducting the illness in the basic unit, as well as any changes and any events should be reported to the clinical trial center by the attending physicians. Therefore, the willingness to cooperate on the part of the clinical research center has nothing to do with interference in the competence of leading physicians, and to a large extent it should increase their credibility in their patients.